USMLE should be appeared for getting into PG/residency which can be just before Graduation so that immediately you can start residency in USA. Technically you are permitted to give the USMLE exam anytime after year 2nd year passing. Since USMLE is a multi step exam consisting of a minimum of 3 exams it is suggested the sooner the better. You can start preparation from 2nd year and appear for 1st step in 3rd year.
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