No. ComedK is open for all.
However reservation is applicable only for 8% of seats which are reserved for students from Hyderabad Karnataka (listed 6 backward districts of Karnataka) region students.
The same Hyderabad Karnataka quota reservation is extended up to 70% in colleges functioning only in the same 6 districts.
The six regions are Bellary, Kalburgi, Yadgir, Koppal, Raichur & Bidar